When an applicant files a substitute specification, the following are required under 37 CFR 1.125: (1) a statement that the substitute specification includes no new matter; (2) a marked-up version of the specification with markings to show all the changes relative to the immediate prior version; and (3) a clean version of the substitute specification.
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Prosecution Pointer, United States Patent and Trademark Office (USPTO), patent application, specification
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