Adam M. Breier Ph.D.
Adam Breier focuses on U.S. patent prosecution, opinion work, and client counseling in the biotechnology and pharmaceutical areas. He prepares domestic and foreign patent applications, and prepares freedom-to-operate and patentability analyses. Dr. Breier has a special interest in subject matter including biochemical and biophysical analytical equipment and methods; stem cells including induced, genetically modified, and mesenchymal stem cells; polymer chemistry; and engineered or recombinant DNA, RNA, and proteins. He also has prosecution experience with compositions and formulations in which hydrophobic or amphipathic materials such as lipids, polymers, or surfactants provide new and useful features, as well as with new chemical entities. Dr. Breier has worked with domestic and foreign clients, including research institutions, startups, and established biotechnology, pharmaceutical, and chemical companies.
Dr. Breier joined Finnegan with 12 years of research experience in molecular biology, genomics, and chemistry. His biological experience includes studying DNA replication and the cell cycle in Saccharomyces cerevisiae, Escherichia coli, and Bacillus subtilis. The work examined how cells choose where to begin the process of copying their chromosomes; how they coordinate the process; the mechanisms they use to respond to problems with replication; and how they make sure each daughter cell receives its copy of the genome. Dr. Breier's chemical and physical experience includes studying the effects of antioxidants on synaptic membranes in a model of neuronal oxidative stress, varying the catalytic properties of aminophenol derivatives using electron-withdrawing and donating substituents, and data analysis for genomic, single molecule fluorescence, and optical tweezers experiments on replicating chromosomes and the physical properties of protein-DNA complexes.
- National Institutes of Health Kirschstein National Research Service Postdoctoral Fellowship, 2005-2008.
- Alan Bearden Outstanding Ph.D. Thesis in Biophysics Award, 2004.
- National Institute of Environmental Health Science Pilot Project Grant, "Coordination of Replication Units in Saccharomyces cerevisiae,"
- Howard Hughes Medical Institute Predoctoral Fellowship, 1999-2004.
- Phi Beta Kappa, 1999.
- University of Kentucky Outstanding Senior in Biology, Merck Index Chemistry Award, Latin Prize, and Greek Prize, 1999.
- Barry Goldwater Scholarship, 1998-1999.
- University of Kentucky Otis A. Singletary Scholarship, 1995-1999.
- Regular contributor to Full Disclosure, Finnegan's patent prosecution update.
- Coauthor. "Reviving Lapsed Patents: Differences Across Jurisdictions and Suggestions for Harmonization," Bloomberg, Aug. 9, 2010.
- Coauthor. "Dynamic Association of the Replication Initiator and Transcription Factor DnaA with the Bacillus subtilis Chromosome During Replication Stress," Journal of Bacteriology, 2008.
- Coauthor. "Whole-Genome Analysis of the Chromosome Partitioning and Sporulation Protein Spo0J (ParB) Levels Spreading and Origin-Distal Sites on the Bacillus subtilis Chromosome," Molecular Microbiology, 2007.
- Coauthor. "Independence of Replisomes in Escherichia coli Chromosomal Replication," Proceedings of the National Academy of Sciences, 2005.
- Coauthor. "Prediction of Saccharomyces cerevisiae Replication Origins," Genome Biology, 2005.
- Coauthor. "Linear Ordering and Dynamic Segregation of the Bacterial Chromosome," Proceedings of the National Academy of Sciences, 2004.